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BlockWinHooks is a sandbox setting in Sandboxie Ini. It specifies whether Sandboxie will allow sandboxed programs to install system-global hooks.
. . . [DefaultBox] BlockWinHooks=n
One application may attach to other applications in the system by employing a mechanism called windows hooks. This mechanism associates a component of the requesting application (called a DLL file) with all other applications.
By default, Sandboxie denies a request to install a global hook, and will instead convert the hook into an application-specific hook, and install this converted hook only into applications running in the same sandbox as the requesting application.
In effect, this restricts the effect of global hooks to a specific sandbox, and increases the protection provided by Sandboxie while still allowing applications that rely on global hooks to execute correctly.
Specifying BlockWinHooks=n disables this protection, and allows a sandboxed application to install global hooks into all running applications, both inside and outside the sandbox.
Related Sandboxie Control setting: Sandbox Settings > Restrictions > Low-Level Access