I have 2 hard drives (OS drive and Data Drive) There is a sandbox folder on each in the default location. I have set to automatically delete on close and the folder on the data drive deletes down to just a few kbits but there are still 38 mb in the folder on the OS drive.
Is that normal

Delete Contents should completely delete the sandbox contents as well as the folder that holds them.
So if C:\Sandbox\(user)\DefaultBox had it's contents deleted, there would be no "DefaultBox" folder showing under C:\Sandbox\(user)

Did you use a "FileRootPath" setting to get sandboxes on two different drives?
That's an advanced setting for a new user, and is not available through the GUI.

Can we see the settings you have for those sandboxes, as well as the settings under the [GlobalSettings] section?
Configure > Edit Configuration
Copy/Paste into a message.

Yes that is what I did by accident. When I first created Sandbox it was default OS drive, and I used it for a bit, then I clicked on my data drive and "moved" the default sandbox to that drive. Once I figured it out I went back to OS and let the program delete, then back to the data drive where I would like the sandbox to be